GrippeEspagneV1, Main, Exploration, bibRecord, 000404

Factors associated with severe disease in hospitalized adults with pandemic (H1N1) 2009 in Spain.

Identifieur interne : 000404 ( Main/Exploration ); précédent : 000403; suivant : 000405

Factors associated with severe disease in hospitalized adults with pandemic (H1N1) 2009 in Spain.

Auteurs : D. Viasus [Espagne] ; J R Pa O-Pardo ; J. Pach N ; A. Campins ; F. L Pez-Medrano ; A. Villoslada ; M C Fari As ; A. Moreno ; J. Rodríguez-Ba O ; J A Oteo ; J. Martínez-Montauti ; J. Torre-Cisneros ; F. Segura ; F. Gudiol ; J. Carratalà

Source :

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases [ 1469-0691 ] ; 2011.

RBID : pubmed:20825436

Descripteurs français

KwdFr :
- Adolescent (MeSH), Adulte (MeSH), Adulte d'âge moyen (MeSH), Espagne (épidémiologie), Facteurs de risque (MeSH), Facteurs âges (MeSH), Femelle (MeSH), Grippe humaine (complications), Grippe humaine (mortalité), Grippe humaine (virologie), Grippe humaine (épidémiologie), Hospitalisation (MeSH), Humains (MeSH), Indice de gravité de la maladie (MeSH), Infections bactériennes (complications), Mâle (MeSH), Obésité (complications), Oséltamivir (pharmacologie), Oséltamivir (usage thérapeutique), Pandémies (MeSH), Pneumopathie infectieuse (complications), Résultat thérapeutique (MeSH), Sous-type H1N1 du virus de la grippe A (MeSH), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Unités de soins intensifs (MeSH), Épidémies de maladies (MeSH), Études prospectives (MeSH).
MESH :
- mortalité : Grippe humaine.
- pharmacologie : Grippe humaine, Infections bactériennes, Obésité, Oséltamivir, Pneumopathie infectieuse.
- usage thérapeutique : Oséltamivir.
- virologie : Grippe humaine.
- épidémiologie : Espagne, Grippe humaine.
- Adolescent, Adulte, Adulte d'âge moyen, Facteurs de risque, Facteurs âges, Femelle, Hospitalisation, Humains, Indice de gravité de la maladie, Mâle, Pandémies, Résultat thérapeutique, Sous-type H1N1 du virus de la grippe A, Sujet âgé, Sujet âgé de 80 ans ou plus, Unités de soins intensifs, Épidémies de maladies, Études prospectives.
Wicri :
- geographic : Espagne.

English descriptors

KwdEn :
- Adolescent (MeSH), Adult (MeSH), Age Factors (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Bacterial Infections (complications), Disease Outbreaks (MeSH), Female (MeSH), Hospitalization (MeSH), Humans (MeSH), Influenza A Virus, H1N1 Subtype (MeSH), Influenza, Human (complications), Influenza, Human (epidemiology), Influenza, Human (mortality), Influenza, Human (virology), Intensive Care Units (MeSH), Male (MeSH), Middle Aged (MeSH), Obesity (complications), Oseltamivir (pharmacology), Oseltamivir (therapeutic use), Pandemics (MeSH), Pneumonia (complications), Prospective Studies (MeSH), Risk Factors (MeSH), Severity of Illness Index (MeSH), Spain (epidemiology), Treatment Outcome (MeSH).
MESH :
- chemical , pharmacology : Oseltamivir.
- geographic , epidemiology : Spain.
- complications : Bacterial Infections, Influenza, Human, Obesity, Pneumonia.
- epidemiology : Influenza, Human.
- mortality : Influenza, Human.
- chemical , therapeutic use : Oseltamivir.
- virology : Influenza, Human.
- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Disease Outbreaks, Female, Hospitalization, Humans, Influenza A Virus, H1N1 Subtype, Intensive Care Units, Male, Middle Aged, Pandemics, Prospective Studies, Risk Factors, Severity of Illness Index, Treatment Outcome.

Abstract

The risk factors for complications in patients with influenza A (H1N1)v virus infection have not been fully elucidated. We performed an observational analysis of a prospective cohort of hospitalized adults with confirmed pandemic influenza A (H1N1)v virus infection at 13 hospitals in Spain, between June 12 and November 10, 2009, to identify factors associated with severe disease. Severe disease was defined as the composite outcome of intensive-care unit (ICU) admission or in-hospital mortality. During the study period, 585 adult patients (median age 40 years) required hospitalization because of pandemic (H1N1) 2009. At least one comorbid condition was present in 318 (54.4%) patients. Pneumonia was diagnosed in 234 (43.2%) patients and bacterial co-infection in 45 (7.6%). Severe disease occurred in 75 (12.8%) patients, of whom 71 required ICU admission and 13 (2.2%) died. Independent factors for severe disease were age <50 years (OR, 2.39; 95% CI, 1.05-5.47), chronic comorbid conditions (OR, 2.93; 95% CI, 1.41-6.09), morbid obesity (OR, 6.7; 95% CI, 2.25-20.19), concomitant and secondary bacterial co-infection (OR, 2.78; 95% CI, 1.11-7) and early oseltamivir therapy (OR, 0.32; 95% CI 0.16-0.63). In conclusion, although adults hospitalized for pandemic (H1N1) 2009 suffer from significant morbidity, mortality is lower than that reported in the earliest studies. Younger age, chronic comorbid conditions, morbid obesity and bacterial co-infection are independent risk factors for severe disease, whereas early oseltamivir therapy is a protective factor.

DOI: 10.1111/j.1469-0691.2010.03362.x
PubMed: 20825436

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 00446
to stream Main, to step Curation: 000446

Le document en format XML

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<term>Adult (MeSH)</term>
<term>Age Factors (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Aged, 80 and over (MeSH)</term>
<term>Bacterial Infections (complications)</term>
<term>Disease Outbreaks (MeSH)</term>
<term>Female (MeSH)</term>
<term>Hospitalization (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Influenza A Virus, H1N1 Subtype (MeSH)</term>
<term>Influenza, Human (complications)</term>
<term>Influenza, Human (epidemiology)</term>
<term>Influenza, Human (mortality)</term>
<term>Influenza, Human (virology)</term>
<term>Intensive Care Units (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Obesity (complications)</term>
<term>Oseltamivir (pharmacology)</term>
<term>Oseltamivir (therapeutic use)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia (complications)</term>
<term>Prospective Studies (MeSH)</term>
<term>Risk Factors (MeSH)</term>
<term>Severity of Illness Index (MeSH)</term>
<term>Spain (epidemiology)</term>
<term>Treatment Outcome (MeSH)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term>
<term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Espagne (épidémiologie)</term>
<term>Facteurs de risque (MeSH)</term>
<term>Facteurs âges (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Grippe humaine (complications)</term>
<term>Grippe humaine (mortalité)</term>
<term>Grippe humaine (virologie)</term>
<term>Grippe humaine (épidémiologie)</term>
<term>Hospitalisation (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Indice de gravité de la maladie (MeSH)</term>
<term>Infections bactériennes (complications)</term>
<term>Mâle (MeSH)</term>
<term>Obésité (complications)</term>
<term>Oséltamivir (pharmacologie)</term>
<term>Oséltamivir (usage thérapeutique)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie infectieuse (complications)</term>
<term>Résultat thérapeutique (MeSH)</term>
<term>Sous-type H1N1 du virus de la grippe A (MeSH)</term>
<term>Sujet âgé (MeSH)</term>
<term>Sujet âgé de 80 ans ou plus (MeSH)</term>
<term>Unités de soins intensifs (MeSH)</term>
<term>Épidémies de maladies (MeSH)</term>
<term>Études prospectives (MeSH)</term>
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<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Oseltamivir</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Spain</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Bacterial Infections</term>
<term>Influenza, Human</term>
<term>Obesity</term>
<term>Pneumonia</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Grippe humaine</term>
<term>Infections bactériennes</term>
<term>Obésité</term>
<term>Oséltamivir</term>
<term>Pneumopathie infectieuse</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Oseltamivir</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Oséltamivir</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Espagne</term>
<term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Age Factors</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Disease Outbreaks</term>
<term>Female</term>
<term>Hospitalization</term>
<term>Humans</term>
<term>Influenza A Virus, H1N1 Subtype</term>
<term>Intensive Care Units</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pandemics</term>
<term>Prospective Studies</term>
<term>Risk Factors</term>
<term>Severity of Illness Index</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Facteurs de risque</term>
<term>Facteurs âges</term>
<term>Femelle</term>
<term>Hospitalisation</term>
<term>Humains</term>
<term>Indice de gravité de la maladie</term>
<term>Mâle</term>
<term>Pandémies</term>
<term>Résultat thérapeutique</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Unités de soins intensifs</term>
<term>Épidémies de maladies</term>
<term>Études prospectives</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Espagne</term>
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<front><div type="abstract" xml:lang="en">The risk factors for complications in patients with influenza A (H1N1)v virus infection have not been fully elucidated. We performed an observational analysis of a prospective cohort of hospitalized adults with confirmed pandemic influenza A (H1N1)v virus infection at 13 hospitals in Spain, between June 12 and November 10, 2009, to identify factors associated with severe disease. Severe disease was defined as the composite outcome of intensive-care unit (ICU) admission or in-hospital mortality. During the study period, 585 adult patients (median age 40 years) required hospitalization because of pandemic (H1N1) 2009. At least one comorbid condition was present in 318 (54.4%) patients. Pneumonia was diagnosed in 234 (43.2%) patients and bacterial co-infection in 45 (7.6%). Severe disease occurred in 75 (12.8%) patients, of whom 71 required ICU admission and 13 (2.2%) died. Independent factors for severe disease were age <50 years (OR, 2.39; 95% CI, 1.05-5.47), chronic comorbid conditions (OR, 2.93; 95% CI, 1.41-6.09), morbid obesity (OR, 6.7; 95% CI, 2.25-20.19), concomitant and secondary bacterial co-infection (OR, 2.78; 95% CI, 1.11-7) and early oseltamivir therapy (OR, 0.32; 95% CI 0.16-0.63). In conclusion, although adults hospitalized for pandemic (H1N1) 2009 suffer from significant morbidity, mortality is lower than that reported in the earliest studies. Younger age, chronic comorbid conditions, morbid obesity and bacterial co-infection are independent risk factors for severe disease, whereas early oseltamivir therapy is a protective factor.</div>
</front>
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<DateCompleted><Year>2011</Year>
<Month>10</Month>
<Day>24</Day>
</DateCompleted>
<DateRevised><Year>2013</Year>
<Month>11</Month>
<Day>21</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1469-0691</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>17</Volume>
<Issue>5</Issue>
<PubDate><Year>2011</Year>
<Month>May</Month>
</PubDate>
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<Title>Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases</Title>
<ISOAbbreviation>Clin. Microbiol. Infect.</ISOAbbreviation>
</Journal>
<ArticleTitle>Factors associated with severe disease in hospitalized adults with pandemic (H1N1) 2009 in Spain.</ArticleTitle>
<Pagination><MedlinePgn>738-46</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1111/j.1469-0691.2010.03362.x</ELocationID>
<Abstract><AbstractText>The risk factors for complications in patients with influenza A (H1N1)v virus infection have not been fully elucidated. We performed an observational analysis of a prospective cohort of hospitalized adults with confirmed pandemic influenza A (H1N1)v virus infection at 13 hospitals in Spain, between June 12 and November 10, 2009, to identify factors associated with severe disease. Severe disease was defined as the composite outcome of intensive-care unit (ICU) admission or in-hospital mortality. During the study period, 585 adult patients (median age 40 years) required hospitalization because of pandemic (H1N1) 2009. At least one comorbid condition was present in 318 (54.4%) patients. Pneumonia was diagnosed in 234 (43.2%) patients and bacterial co-infection in 45 (7.6%). Severe disease occurred in 75 (12.8%) patients, of whom 71 required ICU admission and 13 (2.2%) died. Independent factors for severe disease were age <50 years (OR, 2.39; 95% CI, 1.05-5.47), chronic comorbid conditions (OR, 2.93; 95% CI, 1.41-6.09), morbid obesity (OR, 6.7; 95% CI, 2.25-20.19), concomitant and secondary bacterial co-infection (OR, 2.78; 95% CI, 1.11-7) and early oseltamivir therapy (OR, 0.32; 95% CI 0.16-0.63). In conclusion, although adults hospitalized for pandemic (H1N1) 2009 suffer from significant morbidity, mortality is lower than that reported in the earliest studies. Younger age, chronic comorbid conditions, morbid obesity and bacterial co-infection are independent risk factors for severe disease, whereas early oseltamivir therapy is a protective factor.</AbstractText>
<CopyrightInformation>© 2010 The Authors. Clinical Microbiology and Infection © 2010 European Society of Clinical Microbiology and Infectious Diseases.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Viasus</LastName>
<ForeName>D</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Hospital Universitari de Bellvitge-IDIBELL, University of Barcelona, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Paño-Pardo</LastName>
<ForeName>J R</ForeName>
<Initials>JR</Initials>
</Author>
<Author ValidYN="Y"><LastName>Pachón</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>Campins</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>López-Medrano</LastName>
<ForeName>F</ForeName>
<Initials>F</Initials>
</Author>
<Author ValidYN="Y"><LastName>Villoslada</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Fariñas</LastName>
<ForeName>M C</ForeName>
<Initials>MC</Initials>
</Author>
<Author ValidYN="Y"><LastName>Moreno</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Rodríguez-Baño</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>Oteo</LastName>
<ForeName>J A</ForeName>
<Initials>JA</Initials>
</Author>
<Author ValidYN="Y"><LastName>Martínez-Montauti</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>Torre-Cisneros</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>Segura</LastName>
<ForeName>F</ForeName>
<Initials>F</Initials>
</Author>
<Author ValidYN="Y"><LastName>Gudiol</LastName>
<ForeName>F</ForeName>
<Initials>F</Initials>
</Author>
<Author ValidYN="Y"><LastName>Carratalà</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><CollectiveName>Novel Influenza A (H1N1) Study Group of the Spanish Network for Research in Infectious Diseases (REIPI)</CollectiveName>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016448">Multicenter Study</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2010</Year>
<Month>11</Month>
<Day>02</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Clin Microbiol Infect</MedlineTA>
<NlmUniqueID>9516420</NlmUniqueID>
<ISSNLinking>1198-743X</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>20O93L6F9H</RegistryNumber>
<NameOfSubstance UI="D053139">Oseltamivir</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001424" MajorTopicYN="N">Bacterial Infections</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004196" MajorTopicYN="N">Disease Outbreaks</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006760" MajorTopicYN="N">Hospitalization</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053118" MajorTopicYN="Y">Influenza A Virus, H1N1 Subtype</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007362" MajorTopicYN="N">Intensive Care Units</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009765" MajorTopicYN="N">Obesity</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053139" MajorTopicYN="N">Oseltamivir</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011014" MajorTopicYN="N">Pneumonia</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012720" MajorTopicYN="Y">Severity of Illness Index</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N" Type="Geographic">Spain</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year>
<Month>9</Month>
<Day>10</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2010</Year>
<Month>9</Month>
<Day>10</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2011</Year>
<Month>10</Month>
<Day>25</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">20825436</ArticleId>
<ArticleId IdType="pii">CLM3362</ArticleId>
<ArticleId IdType="doi">10.1111/j.1469-0691.2010.03362.x</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Espagne</li>
</country>
<region><li>Catalogne</li>
</region>
<settlement><li>Barcelone</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Campins, A" sort="Campins, A" uniqKey="Campins A" first="A" last="Campins">A. Campins</name>
<name sortKey="Carratala, J" sort="Carratala, J" uniqKey="Carratala J" first="J" last="Carratalà">J. Carratalà</name>
<name sortKey="Fari As, M C" sort="Fari As, M C" uniqKey="Fari As M" first="M C" last="Fari As">M C Fari As</name>
<name sortKey="Gudiol, F" sort="Gudiol, F" uniqKey="Gudiol F" first="F" last="Gudiol">F. Gudiol</name>
<name sortKey="L Pez Medrano, F" sort="L Pez Medrano, F" uniqKey="L Pez Medrano F" first="F" last="L Pez-Medrano">F. L Pez-Medrano</name>
<name sortKey="Martinez Montauti, J" sort="Martinez Montauti, J" uniqKey="Martinez Montauti J" first="J" last="Martínez-Montauti">J. Martínez-Montauti</name>
<name sortKey="Moreno, A" sort="Moreno, A" uniqKey="Moreno A" first="A" last="Moreno">A. Moreno</name>
<name sortKey="Oteo, J A" sort="Oteo, J A" uniqKey="Oteo J" first="J A" last="Oteo">J A Oteo</name>
<name sortKey="Pa O Pardo, J R" sort="Pa O Pardo, J R" uniqKey="Pa O Pardo J" first="J R" last="Pa O-Pardo">J R Pa O-Pardo</name>
<name sortKey="Pach N, J" sort="Pach N, J" uniqKey="Pach N J" first="J" last="Pach N">J. Pach N</name>
<name sortKey="Rodriguez Ba O, J" sort="Rodriguez Ba O, J" uniqKey="Rodriguez Ba O J" first="J" last="Rodríguez-Ba O">J. Rodríguez-Ba O</name>
<name sortKey="Segura, F" sort="Segura, F" uniqKey="Segura F" first="F" last="Segura">F. Segura</name>
<name sortKey="Torre Cisneros, J" sort="Torre Cisneros, J" uniqKey="Torre Cisneros J" first="J" last="Torre-Cisneros">J. Torre-Cisneros</name>
<name sortKey="Villoslada, A" sort="Villoslada, A" uniqKey="Villoslada A" first="A" last="Villoslada">A. Villoslada</name>
</noCountry>
<country name="Espagne"><region name="Catalogne"><name sortKey="Viasus, D" sort="Viasus, D" uniqKey="Viasus D" first="D" last="Viasus">D. Viasus</name>
</region>
</country>
</tree>
</affiliations>
</record>

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   |texte=   Factors associated with severe disease in hospitalized adults with pandemic (H1N1) 2009 in Spain.
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	Serveur d'exploration sur la grippe en Espagne
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Factors associated with severe disease in hospitalized adults with pandemic (H1N1) 2009 in Spain.

Factors associated with severe disease in hospitalized adults with pandemic (H1N1) 2009 in Spain.

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